CoQ10 Benefits Inflammation

Many metabolic diseases can be attributed to chronic inflammation. The effect of Coenzyme Q₁₀ (CoQ₁₀, ubiquinone-10) on inflammatory markers in patients with metabolic disease has recently been evaluated. CoQ₁₀  is a compound produced by the body and stored in the cell’s mitochondria. It not only acts as a key cofactor in the mitochondrial electron transport system, it is also a potent antioxidant and modulator of gene expression.

In one recent review, the effects of CoQ₁₀ on inflammation were examined in patients with existing clinical inflammatory markers. Nine trials involving 428 subjects were included in this meta-analysis. The daily dose of CoQ₁₀ varied from 100 to 500 mg, and all control groups received placebo. CoQ₁₀ supplementation was demonstrated to significantly improve the serum level of CoQ₁₀ by 1.17 µg/ml [[MD = 1.17, 95% CI (0.47 to 1.87) μg/ml, I2 = 94%].  It also decreased TNF-α by 0.45 pg/ml [MD = -0.45, 95% CI (-0.67 to -0.24) pg/ml, I2 = 0%]...