With more and more research highlighting the importance of maintaining healthy vitamin D levels, patients require a form that is bioavailable, easy-to-take and in a clinically useful dosage. Bio-DK-Mulsion™ delivers 25 ug (1000 IU) of vitamin D3, with vitamins K1 (as phytonadione) and K2 (as MK-7, menaquinone-7) in a micro-emulsified formula.
Vitamins D and K work synergistically to optimize bone and heart health. More specifically, vitamin K activates the matrix Gla-protein (MGP), a vitamin K dependent protein (VKDP) that helps direct calcium to bones and teeth, and away from the arteries. Both osteocalcin (responsible for putting calcium into bones) and MGP (preventing calcium deposits in arteries and soft tissues) are vitamin K dependent.
Clinical data shows this emulsified form increases bioavailability over 200% compared to the non-emulsified form. In addition, Bio-DK-Mulsion™ is absorbed first through the lymphatic system, the body’s preferred route of administration, and then transported to the blood circulation.
Vitamin D, a nutrient synthesized in our skin when exposed to sunlight, can also be found in some foods such as oily fish, beef liver, egg yolks, mushrooms and some fortified foods such as milk and breakfast cereal. Surprisingly, however, nearly half of the American population is deficient in vitamin D,⁽1⁾ with serum of 25-hydroxy vitamin D concentrations less than 20 ng/mL (50 nmol/L).
While we are familiar with the importance of vitamin D in calcium absorption and bone metabolism, many may not be aware of burgeoning research on vitamin D, and the widening range of applications available for cholecalciferol, which can be classified as both a vitamin and a pro-hormone.⁽2)
Vitamin D Deficiency and Musculoskeletal Health
Vitamin D deficiency is associated with dull, achy musculoskeletal pain that is incompletely responsive to both pharmacologic and manual therapies. The pain may be widespread or confined to a particular area, most commonly the lower back and lumbar spine. The process by which this occurs has been clearly defined.
This occurs via multiple pathways including direct genomic/nutrigenomic effect where vitamin D reduces gene expression for inflammatory pathways; the modulation of the microbiome; and, also, via the mitochondria.⁽⁷⁾ Because vitamin D may modulate inflammatory responses, preliminary evidence suggests vitamin D deficiency may also be particularly common among patients with inflammatory and autoimmune disorders.
Each Drop: Vitamin D3 (as cholecalciferol) 25 mcg's (1000 IU's), Vitamin K1, 48 mcg's Vitamin K2 as Menaquinone-7, 12 mg's.