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Dietary Methyl Donors & Biological Aging
A recently published issue of Scientific Reports includes an analysis of the association between the consumption of methyl donor nutrients (MDNs) and phenotypic aging. MDNs are known to play a role in DNA methylation and gene expression, as well as one-carbon and cellular metabolism. Several epigenetic clocks utilize changes in DNA methylation alone to predict…
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Nutrient Intake & Healthy Aging
An interesting analysis of nutrition and aging appeared in BMC Biology, in which the authors used a multi-dimensional modeling technique termed the Geometric Framework for Nutrition (GFN) to assess how the balance of nutrient intakes is associated with the aging process, specifically with age-associated dysregulation. In contrast to what they refer to as the “one…
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Aging & Multi-omics
Results of a multi-omics study that profiled the molecular changes that occur as part of the aging process were recently published in Nature Aging. In sum, they found that there are non-linear patterns in the majority of the -omics related to aging and that two distinct periods of substantial dysregulation occur, one at age 44…
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Air Pollution & Aging
A recently proposed stricter regulation of fine particulate matter (PM2.5) by EPA is a step toward significant reductions in morbidity and mortality, supported by many recently published articles that point to a broad range of adverse health consequences linked to air pollution. An analysis previously published in JAMA Network Open indicates that PM2.5 levels are…
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Nutrient Intake & Healthy Aging
An interesting analysis of nutrition and aging was recently published in BMC Biology, in which the authors used a multi-dimensional modeling technique termed the Geometric Framework for Nutrition (GFN) to assess how the balance of nutrient intakes is associated with the aging process, specifically with age-associated dysregulation. In contrast to what they refer to as…
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Calorie Restriction & Aging
Researchers from the Yale Center for Research on Aging recently published a paper in Science detailing results of a 2-year calorie restriction trial in humans, as well as subsequent animal data which followed up on their findings. A subset of participants in the CALERIE trial (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy)…