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Vitamin B12 Updates
Hand-foot syndrome BMJ published the results of a multi-center randomized and placebo-controlled double-blind phase 3 trial evaluating the efficacy of oral methylcobalamin (vitamin B12) to help prevent hand-foot syndrome among women receiving capecitabine treatment for human epidermal growth factor receptor 2 (HER2) negative early breast cancer. A range of 29–73% of women receiving treatment with…
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L-Carnitine, Selenium & Thyroid Health
Researchers from the University of Turin published the results of a prospective, randomized, and controlled trial evaluating the use of L-carnitine and selenium when combined with standard therapy for Graves’ disease, an autoimmune disorder that affects the thyroid gland. This study follows a previously published pilot study, which found that 500 mg of L-carnitine in…
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What’s In Our Drinking Water ?
Trihalomethanes The results of a cohort study published in JAMA Network Open show the effect of trihalomethanes in community drinking water on the risk of chronic kidney disease (CKD). Trihalomethanes (THMs) are one of several unintended byproducts of chlorination, and include chloroform and three brominated compounds (bromodichloromethane, dibromochloromethane, and bromoform), with the latter more common…
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Mitochondria & Muscular Health
Findings from a 2023 study published in The American Journal of Physiology – Cell Physiology underscore that skeletal muscle is strongly dependent on mitochondrial integrity and the regulation of cellular senescence. This relationship becomes evident when either system is disrupted, as senescent cell accumulation can impede mitochondrial function, compromising muscle adaptability and systemic resilience.
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Women, Alzheimer’s & Lipids
The journal Alzheimer’s & Dementia published the results of a lipidomics study, which found significant differences in plasma lipids associated with Alzheimer’s disease (AD), but only among women. This study was a post hoc analysis of data from two cohorts, the AddNeuroMed and Dementia Case Register cohorts, both conducted among European populations. A total of…
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Glaucoma, Homocysteine, and One Carbon Metabolism
A study published in Cell Reports Medicine examined the role of homocysteine in glaucoma development and progression, including models of glaucoma, clinical data, and Mendelian randomization, and suggests that several B vitamins have a promising role as neuroprotective agents. Homocysteine elevations have been linked to a number of neurodegenerative diseases, but it has been difficult…
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Pulmonary Health & Nutrition Support
The results of a network meta-analysis, which evaluated the use of various nutritional supplements for chronic obstructive pulmonary disease (COPD), were published in BMC Pulmonary Medicine. This analysis included 37 randomized and controlled trials, a total of nearly 2,000 participants with COPD, and 21 nutritional interventions. Network analysis allows for a rough comparison between interventions…
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Air Pollution & Dementia
The Lancet Planetary Health has published a systematic review and meta-analysis of studies examining the association between air pollution and incident dementia. This review was intended to summarize all previous reviews, identify specific gaps in data, and incorporate new primary research. It included data from 32 studies and a pooled population of over 26 million…
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Detox & Depression
Depression is increasingly recognized as a complex, multisystemic condition that extends well beyond neurotransmitter imbalance. Growing evidence reveals a compelling connection between compromised detoxification pathways and the development of depressive symptoms, suggesting that reduced capacity to eliminate toxins can drive systemic inflammation, mitochondrial dysfunction and neurochemical alterations. This evolving perspective broadens understanding of depression’s underlying…
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Lp(a) & Cardiovascular Health
Panvascular disease, or PVD, is an emerging clinical concept referring to a multisite atherosclerotic process that occurs simultaneously or sequentially, affecting multiple vascular beds (e.g., coronary, cerebral, peripheral, etc.). With this approach as its focus, the journal Lipids in Health and Disease published a review which looked at the significance of lipoprotein(a) in PVD. Lipoprotein(a)…