Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected by either celiac disease (CD) or wheat allergy (WA). Although NCGS is triggered by gluten-containing cereals, the offending dietary protein has not been identified yet, and could include other…

Depression, a mental disorder associated with decreased productivity, poor psychosocial outcomes, and decreased quality of life, is a significant public health problem affecting millions of people in the US and elsewhere. Epidemiological studies have examined the association of low zinc (Zn) status with depression, but clinical trials on the effect of Zn supplementation in depression…

Canadian Researchers from nine different research institutions participated in a two-year randomized, controlled, double-blind clinical study to measure the disease modifying effect of chondroitin sulfate (CS) vs. Celecoxib (CE) on cartilage volume loss (CVL) in knee osteoarthritis (OA), and compare the effects of CS and CE on the symptoms of knee OA. Patients were treated…

Researchers examined cross-sectional associations of dietary magnesium intake with fasting glucose (FG) and fasting insulin (FI), associations of magnesium-related SNPs with FG and FI, and interactions between dietary magnesium (Mg) intake and both Mg-related and glycemia-related SNPs on FG and FI in meta-analysis of 15 cohort studies including more than 50,000 participants (Cohorts for Heart…

Researchers conducted a double-blind randomized placebo-controlled study, assigning 27 Crohn’s disease (CD) patients in remission to 2000 IU/day of vitamin D3 or placebo for 3 months. They determined intestinal permeability (IP), plasma-cathelicidin (LL-37), human-beta-defensin-2 (hBD2), disease activity [Crohn’s Disease Activity Index (CDAI)], c-reactive protein (CRP), fecal calprotectin, Quality of Life (QoL) and serum vitamin d…

Melatonin is an uncommonly effective direct free radical scavenger and indirect antioxidant. It detoxifies both reactive oxygen species (ROS) and reactive nitrogen species (RNS), both of which are produced in the brain. Researchers from the Dept. of Cellular and Structural Biology, University of Texas Health Science Center in San Antonio, conducted and published a review…

Mounting evidence supports a protective effect of high 25(OH)D, an indicator of vitamin D status, on risk of various cancers including lung cancer. Researchers carried out a dose-response meta-analysis to elucidate the 25(OH)D – lung cancer association. Eligible studies were identified by searching PubMed and EMBASE databases, and the summary relative risks (RRs) with 95%…

In this study, researchers looked at magnesium intake and the risk of progression to type 2 diabetes from incident prediabetes and/or insulin resistance. After adjusting for age (participants were 26-81 yrs old at baseline) and energy intake, those with the highest magnesium intake had a 37% lower risk of incident metabolic impairment as compared to…

A human study of 420 severe heart failure patients (Q-SYMBIO) compared individuals randomly selected to take CoQ10 or placebo, and who were monitored for 24 months. The goal was to measure the time it took for patients to experience a major adverse cardiovascular event (MACE), including cardiovascular death. The research showed that CoQ10 reduced the…

In a randomized, placebo controlled trial, more than 600 patients (vet¬erans, almost all male) with mild to moderate Alzheimer disease, were studied. Participants took 2000 IU of vitamin E daily, Namenda (memantine), both or neither. Note: all patients were taking a acetylcholinesterase inhibitor at enrollment time. During an average 2.3 year follow-up, patient decline was…