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Vitamin B12 Updates
Hand-foot syndrome BMJ published the results of a multi-center randomized and placebo-controlled double-blind phase 3 trial evaluating the efficacy of oral methylcobalamin (vitamin B12) to help prevent hand-foot syndrome among women receiving capecitabine treatment for human epidermal growth factor receptor 2 (HER2) negative early breast cancer. A range of 29–73% of women receiving treatment with…
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Vitamin B12 & Neurological Health in Older Adults
A recent study published in Annals of Neurology suggests that optimal vitamin B12 thresholds in older adults may need to be re-evaluated, and that subclinical deficiencies may be responsible for neurological deficits. Much has been published previously describing the poor sensitivity of serum B12 as a functional biomarker for vitamin B12 status, as well as…
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B12 Supplementation & Breast Milk
Results of a randomized and controlled trial were recently published in the American Journal of Clinical Nutrition, providing more detail on the efficacy and timing of B12 supplementation given pre- and postnatally in the human milk (HM) concentration of B12. Pregnant women between 12-27 weeks gestation were recruited for this study from Tanzania, an area…
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Vitamin B2 & Cognitive Health
Results of a cross-sectional study were recently published in the Journal of Translational Medicine, detailing the association between vitamin B2 (riboflavin) intake and cognitive function in an older population. Datasets from two cycles of NHANES (between 2011 and 2014) from more than two thousand adults over age 60 who had undergone cognitive function testing and…
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The Methylcobalamin Effect
Vitamin B12 plays a key role in the normal functioning of the brain and nervous system (and the formation of blood). One of its analogs, methylcobalamin, which is considered an active form of vitamin B12, exerts neural protection by encouraging the regeneration of injured nerves and serving as an essential vitamin for promoting proper brain…