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Curcumin, Diabetes & Cardiovascular Risk
Scientific Reports, one of the Nature journals, has recently published the results of a randomized clinical trial evaluating the supplementation of curcumin on clinical outcomes and atherosclerotic cardiovascular disease risk (ASCVD) among diabetic participants. This was an open-label randomized and controlled trial, with analysis of 72 diabetic participants (aged 50-74) with a calculated 10-year ASCVD…
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Lp(a) & Cardiovascular Health
Panvascular disease, or PVD, is an emerging clinical concept referring to a multisite atherosclerotic process that occurs simultaneously or sequentially, affecting multiple vascular beds (e.g., coronary, cerebral, peripheral, etc.). With this approach as its focus, the journal Lipids in Health and Disease published a review which looked at the significance of lipoprotein(a) in PVD. Lipoprotein(a)…
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Lifestyle Factors & Cardiovascular Events Among Diabetics
BMC Medicine recently published a post hoc analysis of the ADVANCE trial, describing the relationship between healthy lifestyle factors (HLF) and the incidence of both microvascular and macrovascular events, as well as overall mortality, among people with type 2 diabetes (T2D) and a high risk for cardiovascular disease. The ADVANCE (Action in Diabetes and Vascular…
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CoQ10 & Cardiac Function
BMC Cardiovascular Disorders recently published the results of a small clinical trial evaluating CoQ10’s effect on cardiac function following a myocardial infarction (MI). One hundred forty-seven study participants had successful percutaneous coronary intervention (PCI) following MI, received standard acute coronary syndrome medications (e.g., aspirin, ticagrelor, clopidogrel, statins, etc.), and were then randomized to either 30mg…
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Cardiometabolic Effects of a Vegan Diet
Recently published in JAMA Network Open were the results of a randomized clinical trial comparing the effects of a vegan or an omnivorous diet on LDL cholesterol (LDL-C) as the primary outcome, with multiple secondary outcomes related to metabolic health. This trial may be the first to recruit adult identical twins, 22 pairs in total,…
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Keto for Cardiovascular Disease
“Summarizing the extensive scientific evidence, the ketogenic diet is a promising nutritional model in the context of cardiovascular disease prevention and therapy. Through its pleiotropic properties, it is able to influence the cardiovascular system on multiple levels. Scientific evidence mostly confirms its beneficial (even more beneficial compared to other diets) effects on the lipid profile…
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TMAO, Gut Microbiota, & Cardiovascular Health
Researchers from Tufts University recently published results from a large community-based cohort in Arteriosclerosis, Thrombosis, and Vascular Biology. They provide details on the associations between both the intake of animal source foods (ASF) and cardiovascular disease risk among older adults, as well as the portion of that risk that appears to be mediated specifically by…
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Childhood Risk Factors for Adult Cardiovascular Events
An analysis of data collected from the International Childhood Cardiovascular Cohorts (i3C) Consortium was recently published in the New England Journal of Medicine, detailing the results of a remarkable study spanning a mean 35 years of follow-up for nearly 40,000 participants. The i3C includes seven cohorts from the US, Finland, and Australia, comprised of children…
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Meal Timing & Cardiovascular Health
Adding to the body of knowledge regarding dietary patterns and cardiovascular disease (CVD), a cross-sectional study was recently published in the Journal of Clinical Endocrinology & Metabolism, revealing an association between the timing of specific foods and CVD risk. Nearly 28,000 adults in the U.S. National Health and Nutrition Examination Survey (NHANES 2003–2016, an ongoing…
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Mitigating the Effect of Air Pollution on Cardiovascular Mortality
A 2018 report published by the National Academy of Sciences, based upon data from 41 cohorts within 16 countries, implicated air pollution (i.e., ambient fine particulate matter (PM2.5)) in the deaths of 8.9 million people in 2015. This parallels the predictions published in the Lancet in 2015, which found ambient PM2.5 to be the 5th…