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Curcumin, Diabetes & Cardiovascular Risk
Scientific Reports, one of the Nature journals, has recently published the results of a randomized clinical trial evaluating the supplementation of curcumin on clinical outcomes and atherosclerotic cardiovascular disease risk (ASCVD) among diabetic participants. This was an open-label randomized and controlled trial, with analysis of 72 diabetic participants (aged 50-74) with a calculated 10-year ASCVD…
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Long-Term Diabetes Program
Results of the U.S. Diabetes Prevention Program (DPP) were first published in 2002 in the New England Journal of Medicine, describing the effects of standard lifestyle recommendations combined with either placebo or metformin, in comparison to a more intensive lifestyle program (which included calorie/fat reduction and exercise, designed to induce at least 7% weight loss)…
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Gene-Diet Interactions in Type 2 Diabetes
The journal Genes (Basel) has published a review of gene-diet interactions in type 2 diabetes mellitus (T2D), describing both the current understanding of genetic risk as well as potential approaches to target genetic risk with nutritional interventions. There is a clear role for hereditary risk in T2D, with first-degree relatives of people with T2D at…
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Glucosamine & Diabetes
The Journal of International Medical Research published a meta-analysis and Mendelian randomization (MR) evaluating the association between glucosamine supplementation and the risk for type 2 diabetes (T2D). Extremely high dose animal studies followed by one previously published human study suggested that glucosamine supplementation might exacerbate insulin resistance when used with osteoarthritis. However, it was too…
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Prediction of Type 2 Diabetes Risk
An analysis recently published in Cardiovascular Diabetology used a cluster-based approach to quantify the risk for developing type 2 diabetes (T2D) among older adults (aged 61-82). Building on a previously published proof-of-concept study, 843 participants in the Kora F4 study were assigned to one of six predefined phenotype clusters, with clusters determined by a number…
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Lifestyle Factors & Cardiovascular Events Among Diabetics
BMC Medicine recently published a post hoc analysis of the ADVANCE trial, describing the relationship between healthy lifestyle factors (HLF) and the incidence of both microvascular and macrovascular events, as well as overall mortality, among people with type 2 diabetes (T2D) and a high risk for cardiovascular disease. The ADVANCE (Action in Diabetes and Vascular…
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Carb Restriction for Type 1 Diabetes
The Society of Metabolic Health Practitioners recently published a position statement on therapeutic carbohydrate reduction for type 1 diabetes in the Journal of Metabolic Health. Noting that nearly 80 percent of adults with type 1 diabetes (T1D) in the US don’t achieve the American Diabetes Association’s (ADA’s) target hemoglobin A1c goal of <7.0% and that…
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Lignan Intake & Diabetes Risk
JAMA Network Open recently published an analysis of several large cohorts of men and women, indicating a lower risk for developing type 2 diabetes with higher dietary intake of lignans, polyphenols abundant in certain plant-based foods. This analysis included data from 3 large prospective U.S. cohorts and over 30 years of follow-up, including the Nurses’…
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Glycemic Load & Gestational Diabetes
Gynecological Endocrinology recently published a systemic review and meta-analysis examining the relationship that glycemic index (GI) and glycemic load (GL) have with gestational diabetes mellitus (GDM), as well as any dose dependence. This analysis included 13 studies (11 observational and 2 case-control) and nearly 40,000 pregnant women. The glycemic index is a score that ranks…
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Telomere Length & Diabetes
Results of a recently released randomized and controlled dietary intervention trial lend support for the use of telomere length as a biomarker for diabetes risk, as well as the effectiveness of dietary interventions to mitigate this risk. Published in Cardiovascular Diabetology, this 5-year study in Spain included 462 participants in the CORonary Diet Intervention with…