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Microbiota & Seasonal Allergies
First introduced in 1989, the “hygiene hypothesis” proposed that exposure to specific microbes, perhaps during crucial windows of development, educates the immune system in a way that modifies the risk for allergic, inflammatory, and autoimmune diseases. Initially, this was proposed in response to the observation that the position of a child in a family (their…
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Gut Microbiota & Immune Alterations in Obesity
Mounting research findings demonstrate the pivotal role the gut microbiota and immune system play in the development and progression of obesity. A 2024 meta-analysis published in Gut Microbes revealed that individuals with obesity have distinct differences in the composition of their microbiome in comparison to controls. Analysis of16S rNA gene and metagenome sequencing data from…
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Microbiota & Seasonal Allergies
First introduced in 1989, the “hygiene hypothesis” proposed that exposure to specific microbes, perhaps during crucial windows of development, educates the immune system in a way that modifies the risk for allergic, inflammatory, and autoimmune diseases. Initially, this was proposed in response to the observation that the position of a child in a family (their…
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An Atlas of Gut Microbiota Plasma Metabolites
In an extraordinary analysis published recently in Nature Communications, researchers in Sweden report the results of a cross-sectional study which, to date, is the largest and most detailed association study between gut microbiota and plasma metabolites. This study had over 8500 participants between the ages of 50 and 64, identified over 1500 microbial species with…
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TMAO, Gut Microbiota, & Cardiovascular Health
Researchers from Tufts University recently published results from a large community-based cohort in Arteriosclerosis, Thrombosis, and Vascular Biology. They provide details on the associations between both the intake of animal source foods (ASF) and cardiovascular disease risk among older adults, as well as the portion of that risk that appears to be mediated specifically by…
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Lean Microbiota vs Obese Microbiota | Systematic Review
Obesity is a severe health problem the world over, affecting 650 million adults worldwide. Shockingly, over 124 million children are also suffering from obesity. For this reason, researchers have become increasingly fascinated with establishing the key factors that could be altered to reduce this health burden on the global human family.