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Intermittent Fasting & Glycemic Control
JAMA Network Open recently published results of a randomized, open-label, active parallel-controlled clinical trial comparing an intermittent fasting program to both metformin and empagliflozin in Chinese adults with early type 2 diabetes. Known as the EARLY (Exploration of Treatment of Newly Diagnosed Overweight/Obese Type 2 Diabetes Mellitus) study, 405 participants were randomized in a 1:1:1…
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High Intensity Interval Training in Older Adults
Results of a randomized and controlled trial were recently published in the Scandinavian Journal of Medicine & Science in Sports, reporting on the effects of high-intensity interval training (HIIT) on cardiorespiratory fitness in older adults. It’s worth noting that cardiorespiratory fitness, often assessed as VO2max (oxygen consumption at a maximum workload), has previously been shown…
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Silymarin & RA
Results of a randomized and controlled clinical trial were recently published in Medicina (Kaunas), evaluating the use of silymarin in combination with conventional disease-modifying antirheumatic drugs (DMARDs) among people with active rheumatoid arthritis (RA). Over an 8-week trial period, 122 participants (85% women) diagnosed with RA and who were receiving conventional treatment (e.g., methotrexate, leflunomide,…
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Celebrate with Nutrient-Rich Summer Foods
As we celebrate the 4th of July, it’s the perfect time to enjoy the bounty of nutritious summer foods. A plethora of research highlights the importance of these seasonal foods in maintaining optimal health. For example, a timeless study published in the American Journal of Clinical Nutrition has shown that consuming a diet rich in…
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Xylitol & Cardiovascular Risk
Concerning findings about the sugar alcohol xylitol were recently published in the European Heart Journal. There were several components in this publication; an untargeted metabolomic study was conducted initially in a cohort of nearly 1,200 stable participants (the discovery cohort) undergoing elective diagnostic cardiac evaluations, and then in a validation cohort of over 2,000 participants.…
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Urolithin A & Neurodegeneration
The journal Alzheimer’s & Dementia recently published results suggesting that urolithin A may have potential benefit for reducing degeneration as a consequence of Alzheimer’s disease (AD) through multiple mechanisms, at least in an animal model. This adds to a growing body of evidence that urolithin A has a critically important role in supporting mitochondrial function,…
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Early Life Pollution & Mental Health
JAMA Network Open recently published an analysis of early life exposure to both air and noise pollution and any association with mental health in adolescence and young adulthood. Amid growing evidence that early exposure to air pollution is linked to a greater risk for the development of several mood and mental health disorders, this study…
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Oral Immunotherapy & the Microbiome
Results of a prospective and longitudinal study conducted among schoolchildren were recently published in Allergology International, describing the association between the gut microbiome and the effectiveness of oral immunotherapy (OIT) for dairy cow’s milk allergy (CMA). Thirty-two children with IgE-mediated CMA received OIT for a period of 13 months, followed by a 2-week period of…
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PFAS & Liver Health
Several studies have been published recently reporting a link between exposure to per- and polyfluoroalkyl substances (PFAS) and metabolic-associated fatty liver disease (MAFLD, a proposed alternative to non-alcoholic fatty liver disease). Notably, MAFLD is growing rapidly, with an estimated prevalence of 100 million people affected in the U.S. alone by 2030, about 1/3 of the…
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Cranberry Extract & the Microbiota
Results of a small human clinical trial recently published in NPJ Biofilms and Microbiomes indicate that short-term use of cranberry extract has a bifidogenic effect and increases the abundance of butyrate-producing bacteria, the first study to report on cranberry-induced microbiome changes. This study was done both to characterize the specific polyphenols and oligosaccharides found within…