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Micronutrient Cocktail & Liver Health
The journal Medicina recently reported the results of a double-blind and placebo-controlled pilot clinical trial evaluating the use of a micronutrient cocktail on parameters associated with liver fibrosis and steatosis among people with obesity and metabolic syndrome. One hundred ninety-six adults (median age 58) with obesity (BMI of 30 kg/m2 or higher, and an elevated…
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Vitamin E & Pediatric NAFLD
Results of a single-blind placebo-controlled trial were recently published in BMC Pediatrics, indicating a beneficial effect of supplementation with vitamin E enriched with tocotrienol (TRF) for children with obesity and non-alcoholic fatty liver disease (NAFLD). This follows a 24-week controlled trial among adults, in which delta-tocotrienol was shown to improve markers of steatosis and hepatocellular…
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Lignan Intake & Diabetes Risk
JAMA Network Open recently published an analysis of several large cohorts of men and women, indicating a lower risk for developing type 2 diabetes with higher dietary intake of lignans, polyphenols abundant in certain plant-based foods. This analysis included data from 3 large prospective U.S. cohorts and over 30 years of follow-up, including the Nurses’…
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EPA & Precision Medicine
The American Journal of Clinical Nutrition recently published a secondary analysis of a randomized and controlled 2×2 factorial trial, revealing a reduction in colorectal polyp formation with EPA ( eicosapentaenoic acid) supplementation when stratified by genotype. Initial results of this study were reported in the Lancet in 2018, in which neither aspirin nor EPA reduced the…
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Obesity & The Microbiome
BMC Microbiology recently published a meta-analysis of metagenomic sequencing data from obese and non-obese participants in an effort to clarify contradictory findings relating the gut microbiome to the risk for an elevated BMI. Seven studies were included in this meta-analysis, as well as 1351 stool metagenomic (shotgun) sequencing files from 862 participants (396 with obesity…
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Silymarin & MASLD
The Journal of Obesity & Metabolic Syndrome recently published the results of a randomized, double-blind, and placebo-controlled clinical trial evaluating the supplementation of silymarin among participants with metabolic dysfunction-associated steatotic liver disease (MASLD). This recent nomenclature, MASLD, applies to people with steatotic liver disease that is attributed to the metabolic syndrome; it has considerable overlap…
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Omega-3s & Lupus (SLE)
Results of a double-blind randomized and placebo-controlled trial evaluating the use of omega-3 fatty acid supplementation among people with systemic lupus erythematosus (SLE) were recently published in Lupus Science & Medicine. 78 adults (97% women) with active SLE were randomized to receive either control (vegetable oil, including olive, palm kernel, and corn oil) or 4…
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Glycemic Load & Gestational Diabetes
Gynecological Endocrinology recently published a systemic review and meta-analysis examining the relationship that glycemic index (GI) and glycemic load (GL) have with gestational diabetes mellitus (GDM), as well as any dose dependence. This analysis included 13 studies (11 observational and 2 case-control) and nearly 40,000 pregnant women. The glycemic index is a score that ranks…
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Keto for Migraines
A paper published recently in Frontiers in Nutrition makes a case for why ketogenic diets with a specific emphasis on sodium supplementation may be an effective prophylactic for migraine. Research is expanding in this area (as was covered in a past blog article) with an increasing number of case reports being published. It’s not certain…
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Modifiable Risk Factors of Cancer
An up-to-date analysis of the number of cancer cases and deaths in the U.S. preventable by modifiable factors was recently published in CA: A Cancer Journal for Clinicians. This analysis was based on data from 2019, estimating the number of cancers (including 30 specific types of cancer, but excluding nonmelanoma skin cancer) that could be…